NAD: The Molecule of Youth? Exploring Its Role in Longevity
Diana
Published in Bloodo Blog · 8 min read · April 25, 2024
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What is NAD and Why Does it Matter?
NAD (NAD+ and NADH), or Nicotinamide Adenine Dinucleotide, is a powerhouse molecule that keeps us vibrant and energetic. It fuels many processes in our body, from muscle movement to breathing – more than 500 enzymatic reactions in our body! Interestingly, NAD also plays a pivotal role in repairing and regulating our genetic material, particularly genes linked to ageing. But here’s the catch – our NAD levels naturally drop, potentially speeding up aging and causing issues like fatigue, poor sleep quality, and reduced mental clarity.
NAD Levels: The Decline and How it Affects You
Scientific studies reveal a tendency for NAD levels to decline with biological age – NAD levels decline by up to 50% between the ages of 40 and 60, impacting cellular health significantly. Generally, the older we get, the lower our NAD levels fall.
However, other factors can contribute to a depletion, including:
Stress Chronic stress can deplete NAD levels, impacting overall cellular function.
Diet A diet high in processed foods and sugar can hinder NAD production.
Certain Medications Some medications may have unintended consequences on NAD levels.
NAD Test Kit
Take Control of Your Well-being – Bloodo™ NAD Level Test provides a clear picture of your NAD levels, allowing you to make informed decisions for a healthier, more energetic you.
NAD influences numerous aspects of our well-being. It’s not just about feeling less tired; optimal NAD levels can improve mental clarity, physical performance, and even the health of your skin and hair. Essentially, maintaining healthy NAD levels can help you feel rejuvenated and energetic, both mentally and physically.
Knowing your NAD levels empowers you to take charge of your health and make informed decisions for a longer, healthier life. By analyzing both NAD+ and NADH levels, we gain insight into the balance of oxidation and reduction within cells, a key indicator of metabolic health and efficiency. NAD+ and NADH levels collectively offer a more accurate marker of biological ageing.
Level Up with NAD: From Fitness to Well-being
NAD, well-known among athletes and gaining traction in sports communities due to its potential benefits, plays a crucial role in optimizing athletic performance. Beyond athletics, sufficient NAD levels can positively impact various aspects of your well-being:
Fitness Boost energy, recovery, and potentially endurance, allowing you to train harder and feel better.
Mood & Mental Wellbeing Potentially improve mood, reduce stress, and support overall mental health.
Sleep Quality Promote deeper sleep for increased energy and cognitive function, aiding both workouts and daily life.
Skin Health May contribute to a more youthful appearance by supporting cellular repair.
Cellular Longevity May promote healthy ageing and potentially reduce the risk of age-related diseases.
Metabolic Health May influence metabolism and insulin sensitivity, aiding weight management.
Taking Control of Your Health with Bloodo
Understanding your NAD levels can be the first step towards a healthier, more energized you. It’s about taking control, making informed decisions, and embracing a proactive approach to health. At Bloodo, we’re committed to helping you unlock your best self. We provide not just tests, but insights based on your results for the longevity journey.
Disclaimer This blog post serves as a starting point for your NAD journey. Consulting a qualified healthcare professional is crucial for personalized recommendations and ensuring your NAD optimization strategy aligns with your overall health goals. The information provided in this blog post is for informational purposes only and should not be construed as medical advice. Always consult with a healthcare professional before making any changes to your diet, exercise routine, or starting a new supplement regimen. It’s crucial to remember that research on NAD is still ongoing, and the evidence for its benefits in these specific areas is developing. While the potential for improvement exists, more studies are needed to establish definitive cause-and-effect relationships.
1. Braidy N, Berg ,J Clement ,J Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. Antioxid Redox Signal. 2019 Jan 10;30(2):251-294. doi: 10.1089/ars.2017.7269. Epub 2018 May 1. PMID: 29634344; PMCID: PMC6277084.
2. Fang ,J Chen W, Hou P, Liu Z, Zuo M, uLi S, Feng ,C Han Y, Li P, Shi ,YShao .C NAD+ metabolismbased immunoregulation and therapeutic potential. Cell Biosci. 2023 May 10;13(1):81. doi: 10.1186/513578-023-01031-5. PMID: 37165408; PMCID: PMC10171153.
3. Li W, Sauve A. NAD+ content and its role ni mitochondria. Methods Mol Biol. 2015;1241:39-48. doi: 10.1007/978-1-4939-1875-1_4. PMID: 25308486.
4. Wilson N, Kataura ,TKorsgen ME, Sun C, Sarkar S, Korolchuk V.l The autophagy-NAD axis ni longevity and disease. Trends Cell Biol. 2023 Sep;33(9):788-802. doi: 10.1016/j.tcb.2023.02.004. Epub 2023 Mar 5. PMID: 36878731.
5. Zhong 0, Wang ,J Tan Y, Lei X, Tang Z. Effects of NAD+ precursor supplementation on glucose and lipid metabolismin humans: a meta-analysis. Nutr Metab (Lond). 2022 Mar 18;19(1):20. doi: 10.1186/51 2986-022-00653-9. PMID: 35303905; PMCID: PMC8932245.
6. Kim HN, Ponte F, Warren A, Ring R, lyer S, Han L, Almeida M. A decrease ni NAD+ contributes to the loss of osteoprogenitors and bone mass with aging. NPJ Aging Mech Dis. 2021 Apr 1;7 (1):8. doi: 10.1038/s41514-021-00058-7. PMID: 33795658; PMCID: PMC8016898.
7. Zhu Y, Zhao KK, Tong Y, Zhou YL, Wang YX, Zhao PQ, Wang ZY. Exogenous NAD(+) decreases oxidative stress and protects H202-treated RPE cells against necrotic death through the upregulation of autophagy. Sci Rep. 2016 May 31;6:26322. doi: 10.1038/srep26322. PMID: 27240523; PMCID: PMC4886526. Kim M, Seol ,J Sato ,TFukamizu Y, Sakurai ,TOkura T.Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance ni Older Japanese Adults: ARandomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. PMID: 35215405; PMCID: PMC8877443.
8. Sharma A, Chabloz S, Lapides RA, Roider E,Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023 Jan 14;15(2):445. doi: 10.3390/nu15020445. PMID: 36678315; PMCID: PMC9861325. Alegre GFS, Pastore GM. NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR):
9. Potential Dietary Contribution to Health. Cur Nutr Rep. 2023 Sep; 12(3):445-464. doi: 10.1007/13668-023-00475-y. Epub 2023 Jun .5 PMID: 37273100; PMCID: PMC10240123.
10. Hayashida S, Arimoto A, Kuramoto Y, Kozako T, Honda S, Shimeno H, Soeda S. Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PARalpha ni mice. Mol Cel Biochem. 2010 Jun;339(1-2):285-92. doi: 10.1007/s11010-010-0391-z. Epub 2010 Feb 1. PMID: 20148352.
11. Walzik D, Jonas W, Joisten N, Belen ,S Wüst RCI, Guillemin G, Zimmer P. Tissue-specific effects of exercise as NAD+ -boosting strategy: Current knowledge and future perspectives. Acta Physiol (Oxf). 2023 Mar; 237(3):e13921. doi: 10.1111/apha.13921. Epub 2023 Jan 10. PMID: 36599416
NAD: The Molecule of Youth? Exploring Its Role in Longevity
What is NAD and Why Does it Matter?
NAD (NAD+ and NADH), or Nicotinamide Adenine Dinucleotide, is a powerhouse molecule that keeps us vibrant and energetic. It fuels many processes in our body, from muscle movement to breathing – more than 500 enzymatic reactions in our body! Interestingly, NAD also plays a pivotal role in repairing and regulating our genetic material, particularly genes linked to ageing. But here’s the catch – our NAD levels naturally drop, potentially speeding up aging and causing issues like fatigue, poor sleep quality, and reduced mental clarity.
NAD Levels: The Decline and How it Affects You
Scientific studies reveal a tendency for NAD levels to decline with biological age – NAD levels decline by up to 50% between the ages of 40 and 60, impacting cellular health significantly. Generally, the older we get, the lower our NAD levels fall.
However, other factors can contribute to a depletion, including:
Chronic stress can deplete NAD levels, impacting overall cellular function.
A diet high in processed foods and sugar can hinder NAD production.
Some medications may have unintended consequences on NAD levels.
NAD Test Kit
Take Control of Your Well-being – Bloodo™ NAD Level Test provides a clear picture of your NAD levels, allowing you to make informed decisions for a healthier, more energetic you.
The Power of NAD: Beyond Energy
NAD influences numerous aspects of our well-being. It’s not just about feeling less tired; optimal NAD levels can improve mental clarity, physical performance, and even the health of your skin and hair. Essentially, maintaining healthy NAD levels can help you feel rejuvenated and energetic, both mentally and physically.
Knowing your NAD levels empowers you to take charge of your health and make informed decisions for a longer, healthier life. By analyzing both NAD+ and NADH levels, we gain insight into the balance of oxidation and reduction within cells, a key indicator of metabolic health and efficiency. NAD+ and NADH levels collectively offer a more accurate marker of biological ageing.
Level Up with NAD: From Fitness to Well-being
NAD, well-known among athletes and gaining traction in sports communities due to its potential benefits, plays a crucial role in optimizing athletic performance. Beyond athletics, sufficient NAD levels can positively impact various aspects of your well-being:
Boost energy, recovery, and potentially endurance, allowing you to train harder and feel better.
Potentially improve mood, reduce stress, and support overall mental health.
Promote deeper sleep for increased energy and cognitive function, aiding both workouts and daily life.
May contribute to a more youthful appearance by supporting cellular repair.
May promote healthy ageing and potentially reduce the risk of age-related diseases.
May influence metabolism and insulin sensitivity, aiding weight management.
Taking Control of Your Health with Bloodo
Understanding your NAD levels can be the first step towards a healthier, more energized you. It’s about taking control, making informed decisions, and embracing a proactive approach to health. At Bloodo, we’re committed to helping you unlock your best self. We provide not just tests, but insights based on your results for the longevity journey.
Disclaimer
This blog post serves as a starting point for your NAD journey. Consulting a qualified healthcare professional is crucial for personalized recommendations and ensuring your NAD optimization strategy aligns with your overall health goals. The information provided in this blog post is for informational purposes only and should not be construed as medical advice. Always consult with a healthcare professional before making any changes to your diet, exercise routine, or starting a new supplement regimen. It’s crucial to remember that research on NAD is still ongoing, and the evidence for its benefits in these specific areas is developing. While the potential for improvement exists, more studies are needed to establish definitive cause-and-effect relationships.
1. Braidy N, Berg ,J Clement ,J Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes. Antioxid Redox Signal. 2019 Jan 10;30(2):251-294. doi: 10.1089/ars.2017.7269. Epub 2018 May 1. PMID: 29634344; PMCID: PMC6277084.
2. Fang ,J Chen W, Hou P, Liu Z, Zuo M, uLi S, Feng ,C Han Y, Li P, Shi ,YShao .C NAD+ metabolismbased immunoregulation and therapeutic potential. Cell Biosci. 2023 May 10;13(1):81. doi: 10.1186/513578-023-01031-5. PMID: 37165408; PMCID: PMC10171153.
3. Li W, Sauve A. NAD+ content and its role ni mitochondria. Methods Mol Biol. 2015;1241:39-48. doi: 10.1007/978-1-4939-1875-1_4. PMID: 25308486.
4. Wilson N, Kataura ,TKorsgen ME, Sun C, Sarkar S, Korolchuk V.l The autophagy-NAD axis ni longevity and disease. Trends Cell Biol. 2023 Sep;33(9):788-802. doi: 10.1016/j.tcb.2023.02.004. Epub 2023 Mar 5. PMID: 36878731.
5. Zhong 0, Wang ,J Tan Y, Lei X, Tang Z. Effects of NAD+ precursor supplementation on glucose and lipid metabolismin humans: a meta-analysis. Nutr Metab (Lond). 2022 Mar 18;19(1):20. doi: 10.1186/51 2986-022-00653-9. PMID: 35303905; PMCID: PMC8932245.
6. Kim HN, Ponte F, Warren A, Ring R, lyer S, Han L, Almeida M. A decrease ni NAD+ contributes to the loss of osteoprogenitors and bone mass with aging. NPJ Aging Mech Dis. 2021 Apr 1;7 (1):8. doi: 10.1038/s41514-021-00058-7. PMID: 33795658; PMCID: PMC8016898.
7. Zhu Y, Zhao KK, Tong Y, Zhou YL, Wang YX, Zhao PQ, Wang ZY. Exogenous NAD(+) decreases oxidative stress and protects H202-treated RPE cells against necrotic death through the upregulation of autophagy. Sci Rep. 2016 May 31;6:26322. doi: 10.1038/srep26322. PMID: 27240523; PMCID: PMC4886526. Kim M, Seol ,J Sato ,TFukamizu Y, Sakurai ,TOkura T.Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance ni Older Japanese Adults: ARandomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022 Feb 11;14(4):755. doi: 10.3390/nu14040755. PMID: 35215405; PMCID: PMC8877443.
8. Sharma A, Chabloz S, Lapides RA, Roider E,Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023 Jan 14;15(2):445. doi: 10.3390/nu15020445. PMID: 36678315; PMCID: PMC9861325. Alegre GFS, Pastore GM. NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR):
9. Potential Dietary Contribution to Health. Cur Nutr Rep. 2023 Sep; 12(3):445-464. doi: 10.1007/13668-023-00475-y. Epub 2023 Jun .5 PMID: 37273100; PMCID: PMC10240123.
10. Hayashida S, Arimoto A, Kuramoto Y, Kozako T, Honda S, Shimeno H, Soeda S. Fasting promotes the expression of SIRT1, an NAD+ -dependent protein deacetylase, via activation of PARalpha ni mice. Mol Cel Biochem. 2010 Jun;339(1-2):285-92. doi: 10.1007/s11010-010-0391-z. Epub 2010 Feb 1. PMID: 20148352.
11. Walzik D, Jonas W, Joisten N, Belen ,S Wüst RCI, Guillemin G, Zimmer P. Tissue-specific effects of exercise as NAD+ -boosting strategy: Current knowledge and future perspectives. Acta Physiol (Oxf). 2023 Mar; 237(3):e13921. doi: 10.1111/apha.13921. Epub 2023 Jan 10. PMID: 36599416